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    Barrier integrity is a vital parameter in evaluating the safety and effectiveness of pharmaceutical formulations. It determines how well drugs and treatments can penetrate biological barriers, such as the skin, gut, or blood-brain barrier, without causing harm or adverse effects. Accurate measurement of barrier integrity is essential for developing safe and effective medications that can reach their target sites within the body.

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    Skin pathology resize
    2 min read

    Investigations into the FLG Null Phenotype:Showcasing the Methodology for CRISPR/Cas9Editing of Human Keratinocytes

    Ever since the association between FLG loss-of-function variants and ichthyosis vulgaris and atopic dermatitis disease onset was identified, FLGs function has been under investigation. Intraindividual genomic predisposition, immunological confounders, and environmental interactions complicate the comparison between FLG genotypes and related causal effects. Using CRISPR/Cas9, we generated human FLG-knockout (DFLG) N/TERT-2G keratinocytes. FLG deficiency was shown…

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    Lab Sydney res
    2 min read

    Advanced pathophysiology mimicking lungmodels for accelerated drug discovery

    Background Respiratory diseases are the 2nd leading cause of death globally. The current treatments for chronic lung diseases are only supportive. Very few new classes of therapeutics have been introduced for lung diseases in the last 40 years, due to the lack of reliable lung models that enable rapid, cost-effective, and high-throughput testing. To accelerate…

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    2024 06 11 skin cells SC res
    1 min read

    The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A

    The aryl hydrocarbon receptor (AHR) is an evolutionary conserved environmental sensor identified as indispensable regulator of epithelial homeostasis and barrier organ function. Molecular signaling cascade and target genes upon AHR activation and their contribution to cell and tissue function are however not fully understood. Multi-omics analyses using human skin keratinocytes revealed that, upon ligand activation,…

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    Shutterstock 2118109721 (1)
    2 min read

    Electrical impedance spectroscopy quantifies skin barrier function in organotypic in vitro epidermis models

    3 D human epidermal equivalents (HEEs) are a state‐of‐the‐art organotypic culture model in preclinical investigative dermatology and regulatory toxicology. Here, we investigated the utility of electrical impedance spectroscopy (EIS) for non–invasive measurement of HEE epidermal barrier function. Our setup comprised a custom–made lid fit with 12 electrode pairs aligned on the standard 24–transwell cell culture…

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