The blood-brain barrier’s role in health and disease

The blood-brain barrier (BBB), as the name states, is a highly selective and protective interface between the bloodstream and the...

Importance of in vitro testing for the 3R’s

Animal testing has long been a fundamental aspect in biomedical research, toxicology studies, and drug development. However, ethical concerns and...

Innovative Microphysiological Model Using HepatoXcell™ Primary Human Hepatocytes and Locsense Artemis

The development of a highly representative in vitro gut-liver model is essential for improving drug testing accuracy while minimizing the...

HMOS 2’FL and 3FL prevent house dust mite induced proinflammatory cytokine release in vitro and decrease specific IgE production in a murine allergic asthma model

Allergic asthma is characterized by sensitization to airborneallergens like house dust mite (HDM). Human milk oligosaccharides (HMOS) are linked to...

Beyond the barriers: impedance-based quality control of in vitro lung models

Chronic pulmonary diseases are a high burden on the healthcare system and on the quality of life (QoL)of its patients....

Guardians of the gateway: exploring the blood-brain barrier with Impedance spectroscopy

The blood-brain barrier (BBB) is a highly specialized and complex physiological structure that plays acrucial role in maintaining the homeostasis...

Electrical impedance spectroscopy: to evaluate and monitororganotypic development and skin barrier function in vitro

For research into skin biology, diseases, and drug or chemical interactions, organotypic 3D human epidermal equivalents (HEEs) are frequently used....

Retina-on-chip: modeling and treating eye diseases in a dish

The human re􀆟na is a highly organized structure consis􀆟ng of neural re􀆟na, re􀆟nal pigment epithelial (RPE)cell layer, and vasculature, called...

Retina-on-chip: Designing a PDMS-based microfluidic chip with 2 μm-thick membranes for culture of iPSC-derived retinal pigment epithelium

Electrical impedance spectroscopy analysis to evaluateorganotypic epidermis formation and barrier function in vitro

For research into skin biology, diseases and drug or chemical interactions, organotypic 3D human epidermal equivalents (HEEs) are frequently used....

Breathing life into innovation: Developing an AdvancedCOPD lung Model for therapeutic discovery

COPD is a major global cause of mortality, but current treatmentsonly provide symptomatic relief. Limited progress in developing new therapies...

Investigations into the FLG Null Phenotype:Showcasing the Methodology for CRISPR/Cas9Editing of Human Keratinocytes

Ever since the association between FLG loss-of-function variants and ichthyosis vulgaris and atopic dermatitis disease onset was identified, FLGs function...

Advanced pathophysiology mimicking lungmodels for accelerated drug discovery

Background Respiratory diseases are the 2nd leading cause of death globally. The current treatments for chronic lung diseases are only...

The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A

The aryl hydrocarbon receptor (AHR) is an evolutionary conserved environmental sensor identified as indispensable regulator of epithelial homeostasis and barrier...

Electrical impedance spectroscopy quantifies skin barrier function in organotypic in vitro epidermis models

3 D human epidermal equivalents (HEEs) are a state‐of‐the‐art organotypic culture model in preclinical investigative dermatology and regulatory toxicology. Here,...

Does all disease begin in the gut?

Nearly 2500 years ago Hippocrates stated, “all disease begins in the gut”. We now understand that impairment of the barrier...

CLDN1 knock out keratinocytes as a model to investigate multiple skin disorders

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