Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier
Big news in skin science! A study in Nature Communications has uncovered a new detail about how our skin's protective...
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HMOS 2’FL and 3FL prevent house dust mite induced proinflammatory cytokine release in vitro and decrease specific IgE production in a murine allergic asthma model
Allergic asthma is characterized by sensitization to airborneallergens like house dust mite (HDM). Human milk oligosaccharides (HMOS) are linked to...
Read moreInvestigations into the FLG Null Phenotype:Showcasing the Methodology for CRISPR/Cas9Editing of Human Keratinocytes
Ever since the association between FLG loss-of-function variants and ichthyosis vulgaris and atopic dermatitis disease onset was identified, FLGs function...
Read moreAdvanced pathophysiology mimicking lungmodels for accelerated drug discovery
Background Respiratory diseases are the 2nd leading cause of death globally. The current treatments for chronic lung diseases are only...
Read moreThe aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A
The aryl hydrocarbon receptor (AHR) is an evolutionary conserved environmental sensor identified as indispensable regulator of epithelial homeostasis and barrier...
Read moreElectrical impedance spectroscopy quantifies skin barrier function in organotypic in vitro epidermis models
3 D human epidermal equivalents (HEEs) are a state‐of‐the‐art organotypic culture model in preclinical investigative dermatology and regulatory toxicology. Here,...
Read moreCLDN1 knock out keratinocytes as a model to investigate multiple skin disorders
The skin serves as an integral barrier between an organism and harmful external stimuli such as allergens, chemicals and infectious...
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