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  • Cosmetics

    Barrier integrity is a crucial factor in assessing the quality and safety of cosmetic products. It determines how well a product interacts with the skin and its ability to protect against external aggressors. A compromised skin barrier can lead to issues such as irritation, dryness, and increased sensitivity. Therefore, accurate measurement of barrier integrity is essential for developing products that are both effective and gentle on the skin.

    Artemis ST Single Transwell 12 wells

    Artemis ST Single Transwell 24 wells

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    Frequently Asked Questions

    Find the answers to questions that are regularly asked by visitors to our website.

    Yes the Artemis is compatible with the incubator. The cells can be placed inside the incubator, while the Artemis detector is placed on top of the incubator.

    Yes, the transwell plates can be placed inside the Artemis plate holder. The device can automatically read-out the entire plate by performing TEER and impedance spectroscopy measurements on all wells.

    Yes, in addition to the standard configuration, Locsense can provide interfacing to microfluidic chips, or organs-on-chip.

    Yes, the Artemis can perform time-lapse measurements, e.g. for a period of 24 hours or 72 hours with time intervals varying from several minutes to hours or days.

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    Meet us at SOT in Orlando

    Locsense will be showcasing its innovative solutions at the Society of Toxicology (SOT) annual conference in Orlando. Join us to explore our latest advancements in toxicology research, connect with industry experts, and discover how Locsense is shaping the future of safety and risk assessment. Mark your calendars and visit us at Booth 532 from March…

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    Installation at Luxembourg Institute of Science and Technology

    We are delighted to announce that Luxembourg Institute of Science and Technology (LIST) is the newest user of our technology for barrier integrity monitoring. This partnership marks a significant step in advancing skin and lung research at LIST. We will keep you up posted on the results that will come out of this collaboration.

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    European Respiratory Society Congress

    Locsense will be attending The European Respiratory Society Congress (ERS), which will be held in Vienna, on September 7 - 11, 2024. For more information, click here. Stop by the Locsense booth to meet our experts and watch live demos. We look forward to seeing you in Vienna.

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    Decoding Skin Resilience

    Researchers from the Radboudumc and Locsense developed an approach to measure how genetic variants, inflammatory mediators, and drug candidates affect skin barrier development and function. The article is now in press in the Journal of Investigative Dermatology. The quantitative and longitudinal analysis of epidermal differentiation and skin barrier function in skin organotypic models was monitored.…

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    ESTIV congress 3 – 6 June 2024 Prague

    Locsense will be exhibiting at the 22nd International Congress of the European Society of Toxicology In Vitro (ESTIV 2024). The congress will take place in the historic and picturesque city of Prague from June 3rd to 6th, 202412. Booth Number: 10 Why Visit Our Booth? For more information about the congress, visit the ESTIV 2024…

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    SOT from 10th-14th of March 2024 in Salt lake city

    Locsense exhibitor at the SOT ToxExpo in Salt Lake City Locsense will exhibit at the 70th SOT Annual meeting and ToxExpo in Salt Lake City, Utah which will be held from the 10-14th of March 2024. The Society of Toxicology promotes the acquisition and utilization of knowledge in toxicology and aids in the protection of…

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    Eurostars funding Epithelial Sensing

    Innovative skin sensing for drug and cosmetic compounds testing Locsense, StratiCELL and the Radboudumc are proud to announce Eurostars funding supporting the development of a breakthrough Epithelial Sensing solution that accurately measures the barrier function of new in-vitro skin constructs, closely resembling the in-vivo situation. The platform assesses skin barrier function in a non-intrusive manner…

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    E2BRN 2023 conference in Edinburgh

    Skin barrier assessment at the E2BRN conference Felicitas Pardow and Jos P.H. Smits from the Radboudumc will present their findings on how impedance spectroscopy provides insight in epidermis formation and skin barrier function in vitro in Edinburgh. Locsense is proud sponsor of the E2BRN (the Epidermal Barrier Research Network) conference on the 28th and 29th …

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    Eurotox from 10th-13th of September 2023 in Ljubjana

    Locsense exhibitor at the Eurotox conference Meet us at the Eurotox conference, in the Ljubjana exhibition and convention center, which will be held from the 10th till the 13th of September 2023. For more details check the Eurotox 2023 website via the following link: https://www.eurotox2023.com/. Stop by our booth to learn more about our in-vitro…

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    Electrical impedance spectroscopy: to evaluate and monitororganotypic development and skin barrier function in vitro

    For research into skin biology, diseases, and drug or chemical interactions, organotypic 3D human epidermal equivalents (HEEs) are frequently used. Studies heavily rely on end-points analysis for which HEEs are harvested to study cellular responses. Non-intrusive methods that enable longitudinal analysis by repetitive measurements can minimize batch effects, increase study reproducibility and maximize experimental throughput.…

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    Retina-on-chip: modeling and treating eye diseases in a dish

    The human re􀆟na is a highly organized structure consis􀆟ng of neural re􀆟na, re􀆟nal pigment epithelial (RPE)cell layer, and vasculature, called the choroid (Figure 1). Current human cell models o􀅌en lack three-dimensional (3D) complexity of the human re􀆟na. Re􀆟nal diseases lead to photoreceptor cell death, causing progressive blindness (1). We are inves􀆟ga􀆟ng two par􀆟cular re􀆟nal diseases:…

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    Electrical impedance spectroscopy analysis to evaluateorganotypic epidermis formation and barrier function in vitro

    For research into skin biology, diseases and drug or chemical interactions, organotypic 3D human epidermal equivalents (HEEs) are frequently used. Studies heavily rely on endpoints analysis for which HEEs are harvested to study cellular responses. Non-intrusive methods that enable longitudinal analysis by repetitive measurements can minimize batch effects, increase study reproducibility and maximize experimental throughput.…

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    Investigations into the FLG Null Phenotype:Showcasing the Methodology for CRISPR/Cas9Editing of Human Keratinocytes

    Ever since the association between FLG loss-of-function variants and ichthyosis vulgaris and atopic dermatitis disease onset was identified, FLGs function has been under investigation. Intraindividual genomic predisposition, immunological confounders, and environmental interactions complicate the comparison between FLG genotypes and related causal effects. Using CRISPR/Cas9, we generated human FLG-knockout (DFLG) N/TERT-2G keratinocytes. FLG deficiency was shown…

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    The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A

    The aryl hydrocarbon receptor (AHR) is an evolutionary conserved environmental sensor identified as indispensable regulator of epithelial homeostasis and barrier organ function. Molecular signaling cascade and target genes upon AHR activation and their contribution to cell and tissue function are however not fully understood. Multi-omics analyses using human skin keratinocytes revealed that, upon ligand activation,…

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    Electrical impedance spectroscopy quantifies skin barrier function in organotypic in vitro epidermis models

    3 D human epidermal equivalents (HEEs) are a state‐of‐the‐art organotypic culture model in preclinical investigative dermatology and regulatory toxicology. Here, we investigated the utility of electrical impedance spectroscopy (EIS) for non–invasive measurement of HEE epidermal barrier function. Our setup comprised a custom–made lid fit with 12 electrode pairs aligned on the standard 24–transwell cell culture…

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