Next Generation
toxicology and drug development instruments
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Taylored solutions for your industry.
Barrier integrity plays a crucial role across various industries, serving unique purposes and addressing specific needs. By maintaining barrier integrity, businesses can ensure the safety, quality, and compliance of their products. Explore your sector below to learn more about the benefits of barrier integrity monitoring and discover the tailored solutions we provide to support your product development and research activities.
Cosmetics
Barrier integrity is a crucial factor in assessing the quality and safety of cosmetic products. It determines how well a product interacts with the skin and its ability to protect against external aggressors. A compromised skin barrier can lead to issues such as irritation, dryness, and increased sensitivity. Therefore, accurate measurement of barrier integrity is essential for developing products that are both effective and gentle on the skin.
Food
In the food industry, maintaining the integrity of barriers within the gastrointestinal tract is crucial for both safety and efficiency. Barrier integrity measurements help monitor and ensure that the gut barrier, essential for nutrient uptake, remains intact and functional. A compromised gut barrier can lead to the infiltration of harmful pathogens or toxins, potentially causing foodborne illnesses. Moreover, an effective gut barrier is vital for optimal nutrient absorption, ensuring that essential nutrients from food are properly absorbed into the body.
By investing in barrier integrity measurements, consumer health is safeguarded, while enhancing the nutritional value of your products.
General
Founded in 2016, Locsense develops non-invasive sensors like the Artemis to monitor cell health, offering a cruelty-free alternative to animal testing. Its technology measures cell barrier strength, crucial for drug testing, disease research, and understanding body defenses. Locsense devices integrate seamlessly with existing workflows and advanced in-vitro platforms like organ-on-chip and microfluidic chips.
Pharmaceuticals
Barrier integrity is a vital parameter in evaluating the safety and effectiveness of pharmaceutical formulations. It determines how well drugs and treatments can penetrate biological barriers, such as the skin, gut, or blood-brain barrier, without causing harm or adverse effects. Accurate measurement of barrier integrity is essential for developing safe and effective medications that can reach their target sites within the body.
Unique benefits
Discover the benefits of Locsense Artemis impedance spectroscopy measurements
Automated TEER / impedance spectroscopy measurements
Monitor the barrier function while cells are situated inside the incubator or on the laboratory bench
User-friendly and workflow compatible
The software is plug and play and the system is easy to operate for first time users
Time-saving
Save time by automating TEER / impedance spectroscopy measurements for several hours or days at the desired time intervals
Non-destructive, semi-continuous
The Artemis operates while cells are located inside the incubator, hood or on the desktop. Measurements are non-destructive and can be performed for days in a row and intervals of your choice.
Compatible with conventional transwell plates
Smart-lids are available for 12 and 24 wells transwell plates, including Nunc, Corning, VWR, Greiner.
Reduced risk of cross contamination
Each well is equipped with a set of electrodes, thereby reducing the risk of cross contamination. All parts in contact with cells are autoclavable
Trusted partner in cell biology.
Boosting Barrier Integrity Research
“We have been working with the Artemis ST in combination with 24 wells plates during a rental period and were impressed by its performance.
Recently, we purchases one, allowing us to continue utilizing it in our experiments. The Artemis has been instrumental in generating reliable data on barrier integrity across various in vitro models, significantly enhancing the robustness of our experimental setups.
Moreover, the Artemis has enabled us to investigate time-dependent barrier effects, which we were previously unable to study in-depth. Its user-friendly interface and space-efficient design make it an excellent addition to our laboratory.
The Locsense team has consistently demonstrated professionalism and dedication, always putting in effort to meet our needs. Their support in experimental setup and data analysis has been very valuable. We look forward to continuing our collaboration with Locsense and incorporating the Artemis further in our research.”
Revolutionizing Laboratory Workflows
“The Artemis has become an essential piece of technology in a majority of the experimental and quality control workflows in our laboratory.
This system has enabled us to establish reliable, rapid and cost-effective methodologies to assess bioelectrical parameters of cells and tissues. This advancement has sped up our development of sophisticated human-like organ and tissue models. The Artemis is now a key tool for testing the quality of these models and assessing the safety of nanoparticles (such as air pollutants), as well as the safety and efficacy of new therapeutics (like extracellular vesicles) for repairing various organs.
Additionally, using the Artemis has significantly reduced the number of tests needed to evaluate the models and decreased the use of plasticware in the lab, contributing to the sustainability of our research. Lastly, the Locsense team has provided exceptional support with experimental setup and data analysis.”
In the news today.
Follow us to stay up to date with the latest developments
Meet us at SOT in Orlando
Locsense will be showcasing its innovative solutions at the Society of Toxicology (SOT) annual conference in Orlando. Join us to explore our latest advancements in toxicology research, connect with industry…
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Installation at Luxembourg Institute of Science and Technology
We are delighted to announce that Luxembourg Institute of Science and Technology (LIST) is the newest user of our technology for barrier integrity monitoring. This partnership marks a significant step…
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European Respiratory Society Congress
Locsense will be attending The European Respiratory Society Congress (ERS), which will be held in Vienna, on September 7 – 11, 2024. For more information, click here. Stop by the Locsense…
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Decoding Skin Resilience
Researchers from the Radboudumc and Locsense developed an approach to measure how genetic variants, inflammatory mediators, and drug candidates affect skin barrier development and function. The article is now in…
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Upcoming webinar on monitoring of the gut barrier function
Upcoming Webinar: “Does all disease begin in the gut? Monitoring the barrier function of an in vitro gut mimic” Join us on May 23rd for an insightful session presented by Eline Geervliet, Application…
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ESTIV congress 3 – 6 June 2024 Prague
Locsense will be exhibiting at the 22nd International Congress of the European Society of Toxicology In Vitro (ESTIV 2024). The congress will take place in the historic and picturesque city…
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Medtech talent event
Locsense is delighted to announce its participation in the upcoming MedTech Talent Event. This event, hosted by the TechMed Centre at the University of Twente, promises to be a dynamic…
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Locsense frontrunner in-vitro sensing
Innovation in In-Vitro Sensing: Discover how Locsense is leveraging cutting-edge technology to become a frontrunner in the field.
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NXTGEN HIGHTECH – Biomed 03: Organ-on-Chip
Kick off NXTGEN HIGHTECH The NXTGEN HIGHTECH biomedical 3 project has officially kicked off with a workshop on Competences, Needs and Gaps in Fabrication for Biomedical Devices on the 4th…
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SOT from 10th-14th of March 2024 in Salt lake city
Locsense exhibitor at the SOT ToxExpo in Salt Lake City Locsense will exhibit at the 70th SOT Annual meeting and ToxExpo in Salt Lake City, Utah which will be held…
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Beyond the barriers: impedance-based quality control of in vitro lung models
Chronic pulmonary diseases are a high burden on the healthcare system and on the quality of life (QoL)of its patients. As the third leading cause of death, chronic respiratory diseases…
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Guardians of the gateway: exploring the blood-brain barrier with Impedance spectroscopy
The blood-brain barrier (BBB) is a highly specialized and complex physiological structure that plays acrucial role in maintaining the homeostasis of the central nervous system (CNS) [1]. Grossly the BBBconsists…
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Electrical impedance spectroscopy: to evaluate and monitororganotypic development and skin barrier function in vitro
For research into skin biology, diseases, and drug or chemical interactions, organotypic 3D human epidermal equivalents (HEEs) are frequently used. Studies heavily rely on end-points analysis for which HEEs are…
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Retina-on-chip: modeling and treating eye diseases in a dish
The human rena is a highly organized structure consisng of neural rena, renal pigment epithelial (RPE)cell layer, and vasculature, called the choroid (Figure 1). Current human cell models oen lack…
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Retina-on-chip: Designing a PDMS-based microfluidic chip with 2 μm-thick membranes for culture of iPSC-derived retinal pigment epithelium
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Electrical impedance spectroscopy analysis to evaluateorganotypic epidermis formation and barrier function in vitro
For research into skin biology, diseases and drug or chemical interactions, organotypic 3D human epidermal equivalents (HEEs) are frequently used. Studies heavily rely on endpoints analysis for which HEEs are…
Read more
Breathing life into innovation: Developing an AdvancedCOPD lung Model for therapeutic discovery
COPD is a major global cause of mortality, but current treatmentsonly provide symptomatic relief. Limited progress in developing new therapies is attributed to the absence of reliable lung models for…
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Investigations into the FLG Null Phenotype:Showcasing the Methodology for CRISPR/Cas9Editing of Human Keratinocytes
Ever since the association between FLG loss-of-function variants and ichthyosis vulgaris and atopic dermatitis disease onset was identified, FLGs function has been under investigation. Intraindividual genomic predisposition, immunological confounders, and…
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Advanced pathophysiology mimicking lungmodels for accelerated drug discovery
Background Respiratory diseases are the 2nd leading cause of death globally. The current treatments for chronic lung diseases are only supportive. Very few new classes of therapeutics have been introduced…
Read moreContact Locsense today.
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Frequently asked questions.
Find the answers to questions that are regularly asked by visitors to our website.
Yes, the transwell plates can be placed inside the Artemis plate holder. The device can automatically read-out the entire plate by performing TEER and impedance spectroscopy measurements on all wells.
Yes, in addition to the standard configuration, Locsense can provide interfacing to microfluidic chips, or organs-on-chip.
Yes, the Artemis can perform time-lapse measurements, e.g. for a period of 24 hours or 72 hours with time intervals varying from several minutes to hours or days.
Yes the Artemis is compatible with the incubator. The cells can be placed inside the incubator, while the Artemis detector is placed on top of the incubator.